Marvel's Spider-Man 2: Walkthrough & Boss Guide

This is a short story overview of Marvel's Spider-Man 2 with notes on its main fights. It is not a mission-by-mission walkthrough, and it does not describe attack patterns or QTE mechanics that could not be verified. The plot and gameplay notes follow Wikipedia. Spoilers for the whole story follow.

Ten months after Miles Morales, Peter Parker starts teaching physics at Brooklyn Visions Academy, where Miles is a student. A rampaging Sandman interrupts class and both Spider-Men subdue him; Peter is fired for leaving his class. Both Spider-Men have Web Wings to glide across the city and can parry physical attacks; some enemy types cannot be dodged, so parrying is necessary against them.

Peter and Mary Jane meet Harry Osborn, who appears fully recovered, and Kraven arrives in New York with his Hunters. During a prison transfer at the Raft, hunters capture Martin Li and Miles fails to stop them. Kraven is hunting super-powered people and has already killed several villains.

At Coney Island, Hunters attack to recapture Tombstone. Harry, now super-powered, sees Peter save civilians and learns his secret. Kraven kidnaps Curt Connors, transforms him into the Lizard, and mortally wounds Peter, but an organic exosuit jumps from Harry to Peter and saves his life. Peter learns the suit is vulnerable to loud noises. Peter and Miles later find Connors and cure him; Connors reveals the suit is an alien symbiote. Peter refuses to remove it, goes on a rampage and nearly kills Mary Jane.

Kraven captures Miles and forces him to fight Martin Li, but Miles frees Li, who points him toward Peter. Peter storms Kraven's fortress and nearly kills him until Miles intervenes. Miles then fights Peter, breaking the symbiote's hold and removing it. Note that the Mister Negative fight is Miles versus Li, not a Peter fight.

Peter takes the symbiote to Oscorp to be destroyed, but Harry takes it back and becomes Venom, kills Oscorp staff and then Kraven in Times Square. He turns Mary Jane into Scream, but Peter helps her break free. Li converts Peter's remaining symbiote traces into Anti-Venom. While Peter and Miles hold Venom off, Mary Jane steals the meteorite that brought the symbiotes to Earth and destroys it with the Foundation's particle accelerator. At Harry's request, Peter destroys the symbiote that controls him, and Harry falls into a coma.