Nioh 2: Walkthrough & Boss Guide
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🗺️ Main Story Walkthrough
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Nioh 2 (Team Ninja / Koei Tecmo) launched on PlayStation 4 on 13 March 2020; the Complete Edition for PS5 and Windows followed on 5 February 2021. This outline follows the 21 main missions as listed on the Fextralife wiki and the story as summarized on Wikipedia, checked on 12 October 2026. Mission names and boss placements are verified; build advice, talisman choices and exact numbers are not covered.
The game is set in the late Sengoku era, mostly as a prequel to Nioh (2017). You create Hide (Hidechiyo), a half-yokai “Shiftling”, who allies with the merchant Tokichiro and the demon hunter Mumyo and later serves Oda Nobunaga. The antagonist is Kashin Koji, a mysterious entity tied to the yokai Otakemaru.
The main missions run in this order: The Village of Cursed Blossoms (recommended level 1; Mezuki), The Beast Born of Smoke and Flames (Enenra), The Viper's Sanctum (Dosan's estate; Yatsu-no-Kami), The Hidden Monsters of Okehazama (Owari Province, May 1560), The Mysterious One Night Castle, and The Hollow Fortress (Inabayama Castle).
Next come A Way Out, Corpses and Ice (Omi), Bird in a Cage, Pervading Waters (Ishiyama Hoganji), The Frenzied Blaze (Honnoji temple), The Sun Sets On Mount Tenno, Ruin Draws Near (Kitanosho Castle), The Two Faces of Hospitality and The High-spirited Demon (Komaki-Nagakuta, then a Tokugawa stronghold). Mezuki appears again in The High-spirited Demon.
The final stretch is The Mausoleum of Evil (Byodo-In; Shuten Doji), The Golden Castle (Jurakudai; Lady Osakabe, with Yatsu-no-Kami, Enenra and Mezuki returning), Cherry Blossom Viewing in Daigo (Kashin Koji, after you defeat Tokichiro a second time), Sealed Fate (Byodo-In), The Blue-eyed Samurai and In the Eye of the Beholder (Otakemaru). Per Wikipedia, Hide frees Tokichiro from Koji's control and seals Otakemaru at Byodo-In, and in the post-credits sequence the arrival of William from Nioh releases Koji, leading to the final battle.
Three post-game DLC chapters set in the Heian period exist: The Tengu's Disciple, Darkness in the Capital and The First Samurai. After finishing the final mission you can start New Game Plus; the Fextralife wiki lists the difficulty tiers as Dream of the Samurai, Dream of the Strong, Dream of the Demon, Dream of the Wise and Dream of the Nioh, with the higher tiers tied to the DLC. Its page is internally inconsistent about the exact unlock conditions, so confirm in-game.
⚔️ Boss Guides
Mezuki
Where
The Village of Cursed Blossoms (first main mission); he returns in The Golden Castle, The High-spirited Demon and In the Eye of the Beholder.
Attacks and notes
Charge (Burst Counter it to stop him and deal Ki damage), three horizontal swipes, Summon Ghosts (three ghosts that explode on contact), and a triple Weapon Slam. In the Dark Realm he is faster, summons more ghosts and gains a ranged slash. The arena is large and open, so keep your distance and punish after his predictable attacks. Drops include the Mezuki Soul Core.
Enenra
Where
The Beast Born of Smoke and Flames (also The Golden Castle).
Attacks and notes
His Tornado attack is the best Burst Counter moment. He also throws five slow tornadoes, slams with a large frontal AoE that leaves a yokai pool, and teleports beside you. Lure him near the four corner pillars; breaking a pillar deals heavy Ki damage but each pillar works only once. Drops include the Enenra Soul Core.
Yatsu-no-Kami
Where
The Viper's Sanctum (also The Golden Castle).
Attacks and notes
Impaling Doom (blade-first charge), a tail sweep, body slam, paralyzing needles, a grapple that cannot be blocked and can kill in one hit, and poison pools. Arms burst from the ground to grab you; severing one stops those attacks. Attack the head while it glows to stun it. In the Dark Realm the arms split into smaller snakes that spit poison. Drops include the Yatsu-no-Kami Soul Core.
Shuten Doji
Where
The Mausoleum of Evil (also a tougher version in the DLC sub mission The Revelry Ends).
Attacks and notes
He drinks, then grapples or sprays fire; his hair can catch fire and swing in a wide circle; he also has jump attacks, a fire stomp and triple club slams. His sake bottle collects stray Amrita; when full, he can drink to trigger the Dark Realm, where he hits harder and takes more damage. Hit-and-run and Burst Counters are the wiki's suggested approach.
Lady Osakabe
Where
The Golden Castle.
Attacks and notes
Her limbs ram or spin at you and fire elemental balls, while the main head casts random attacks. Attack one limb until its Ki runs out; it drops to the roof and is easy to hit. After four limbs fall she staggers and her main head drops, giving a damage window. Her red eyes are weak points.
Kashin Koji
Where
Cherry Blossom Viewing in Daigo, after you defeat Tokichiro for the second time. Fextralife lists him as a yokai mage who uses elemental attacks. Per the wiki he is a human form of Otakemaru, taking shape from Anima that escaped Otakemaru's weakened seal at Byodo-In; he is not a separate boss from the one in the final mission.
Notes
Keep moving in phase one and dodge-counter when he teleports next to you. Grappling him leaves him down for a long time. In the later phases get far from his Burst Clone attack and guard against Sword Rain.
Otakemaru
Where
In the Eye of the Beholder (final main mission); he also appears in DLC missions.
Phases
He first cycles through Feral, Brute and Phantom yokai forms, then fights with a one-handed sword that is Fire, Water or Lightning aligned (each with its own attack set), and in the final phase summons four floating hands and swaps swords faster. The wiki's health thresholds for these phases are inconsistent. Burst Counter the Feral Burst; run in circles against slow projectiles; guard against the final-phase Elemental Disc and Sword Rain. He drops the Otakemaru Soul Core.
Sources & fact-check
Release facts, mechanics and boss details on this page were checked against these sources on 12 October 2026. Spotted an error? Tell us.