Devil May Cry 5: Walkthrough & Boss Guide

This page is a mission-by-mission outline of Devil May Cry 5 with the bosses each mission contains. Mission names and bosses follow the Samurai Gamers mission list and the story and character notes follow Wikipedia. It does not cover secret missions, orb locations or every enemy, and the boss notes are brief because detailed attack patterns have not been verified.

The game opens with a cinematic showing the demon Urizen draining the Qliphoth tree. Mission 1 puts you in control of Nero in the ruins of Redgrave City with the Red Queen sword and Blue Rose revolver. Nero also uses Devil Breakers, robotic arms with effects such as grabbing enemies or stopping time; Wikipedia notes they are powerful but break if misused.

Mission 2 (Qliphoth) ends with the boss fight against Goliath, and Mission 3 (Flying Hunter) ends with Artemis; both are covered in the boss section below.

Mission 4 (V) introduces V, who doesn't use weapons: he summons the familiars Griffon (ranged lightning), Shadow (blades and portals) and Nightmare (a golem with melee and laser attacks), whose attacks can't kill, so V finishes enemies with his cane. It ends against Nidhogg. Mission 5 (The Devil Sword Sparda) is the Elder Geryon Knight fight, and Mission 6 (Steel Impact) is the Gilgamesh fight. Dante switches between four styles during combat and uses Rebellion, the Devil Sword Sparda and new Devil Arms.

Mission 7 (United Front) has the Proto Angelo and Scudo Angelo bosses, Mission 8 (Demon King) is the first big fight against Urizen, and Mission 9 (Genesis) lists no boss.

Mission 10 (Awaken) is another fight against Urizen, Mission 11 (Reason) ends with Cavaliere Angelo, and Mission 12 (Yamato) is a third Urizen encounter.

Mission 13 (Three Warriors) lists no boss. Missions 14 to 16 are the three “Diverging Point” missions: 14 (V) lists Cavaliere Angelo, Goliath and Artemis, 15 (Nero) lists Malphas, and 16 (Dante) lists King Cerberus.

Mission 17 (Brothers) lists Urizen as its boss, and Mission 18 (Awakening) lists Griffon, Shadow and Nightmare.

In Mission 19 (Vergil) Dante fights Vergil; guides describe it as the game's hardest fight and warn that Vergil deflects ranged attacks. Mission 20 (True Power) is the final story mission: Nero takes over and fights Vergil, as Wikipedia confirms. Per Wikipedia's plot summary, Urizen is defeated but V merges with him, restoring Vergil; after Nero defeats Vergil, Vergil and Dante go to the Underworld to cut down the Qliphoth and seal its portal while Nero stays behind. Weeks later, Trish and Lady take a job from Morrison and Dante and Vergil spar as friendly rivals. The ending does not set up the events of the original Devil May Cry. We could not verify an achievement tied to holding SSS rank in the final missions, so none is mentioned.