Diablo IV: Walkthrough & Boss Guide
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🗺️ Main Story Walkthrough
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This is a short story overview with notes on three campaign bosses, not a complete walkthrough. The campaign has a Prologue, six acts and an Epilogue, titled Wandering, A Cold and Iron Faith, The Knife Twists Again, The Making of Monsters, A Gathering Storm, Secrets Bartered, Fates Sold, Dance of the Makers and From the Wound Spilled. Acts 1 to 3 can be played in any order; Acts 4 to 6 follow in sequence. Region-to-act details for Acts 3 to 6 and recommended levels are not given by the sources we loaded, so they are not stated here. Spoilers follow.
The Wanderer is drugged by villagers loyal to Lilith and meets the Horadrim Lorath Nahr, who explains the prophecy of her return. The opening quests start in the Fractured Peaks and the town of Nevesk. Fextralife names X'Fal, the Scarred Baron, in Icehowl Ruins as the early boss in this area. Lilith appears in the Chapel near Nevesk during the Prayers for Salvation quest.
Act 2 is set in Scosglen. Astaroth possesses Donan's son Yorin and is fought at Cerrigar during the quest As the World Burns; Yorin dies when Astaroth is defeated (see the boss entry). The Wanderer also visits Rathma's sanctum, where Inarius kills Rathma.
Wikipedia describes the middle stretch as follows. In the Dry Steppes the Wanderer pursues Elias, Lorath's former apprentice, who summoned Lilith. Andariel is summoned and defeated, and Elias is finally killed in Hawezar after his immortality is broken. In Caldeum the Wanderer defeats Duriel. The Fextralife wiki describes Act 5 as the longest act of the campaign and Act 4 as the shortest. We could not match each of these events to a specific act number from the sources loaded, so the act numbers are left out.
Act 6 takes place across several places in Sanctuary, leading to the finale. Inarius is killed by Lilith in Hell. At Mephisto's Cathedral of Hatred, per Wikipedia, the Wanderer defeats Lilith while Neyrelle uses the Soulstone to contain Mephisto. Neyrelle then leaves with the Soulstone to look for a way to defeat the Prime Evils. There is no level requirement stated for the Lilith fight; Fextralife lists none.
⚔️ Boss Guides
Astaroth
Attack Patterns
Astaroth is a required campaign boss at Cerrigar, Scosglen, during the quest As the World Burns. Phase 1 has him on his hound, the Amalgam of Rage: Flame Breath (three fire beams), Lunge Smash (leaps to three random spots), Fiery Swipe (a wide melee arc then three fireballs that detonate) and Meteor Rain. In phase 2 he is unmounted while the Amalgam recovers at the center: a Blood Pool spreads under the beast, and he uses Staff Swing as the safe area shrinks, Fiery Charge that leaves lines of fire, Flame Wave and Multi-Meteor Rain. In phase 3 both attack together and Astaroth summons Lycan Wolves.
Strategy
Fextralife recommends killing the wolves quickly and focusing on Astaroth, since killing the Amalgam only returns the fight to phase 2.
Andariel, Maiden of Anguish
Attack Patterns
Andariel is a mandatory story boss in Blasted Scarp during the quest Anguish Incarnate; she spawns after the quest cutscene. In phase 1 her arms are chained to a wooden structure so she moves slowly, rune chains slow you if you touch them, she casts two telegraphed red beam patterns (a Y-pattern and a cone) while standing still, and she occasionally teleports out and fires projectiles. Phase 2 starts at 25% health: she looks like her Diablo II form, moves faster and uses claw swipes, a claw shove and two chain attacks (a downward swing and a side lash).
Strategy
Dodge between the gaps in the red beam patterns in phase 1, and in phase 2 sidestep her attacks and avoid the rune chains. Rewards include gold, XP, the Brimstone Mount and a chance at Unique Boss Pool drops. Wikipedia places her summoning and defeat in the Dry Steppes.
Lilith, Daughter of Hatred
Attack Patterns
The Fextralife page lists Lilith as a required campaign fight at the Throne of Hatred, tied to the quest What Lies Ahead (Wikipedia names the Cathedral of Hatred). In her human form she uses ground tears, wing swipes and demonic jumps; at 75% health she flies off and returns with minions to clear, and at 50% and 25% she summons a Dreadful Champion of Chaos (one, then two). When her health runs out she transforms into the Daughter of Hatred form, creating corrupted blood pools and using aerial whirlwinds, wing and tail strikes and blood bubbles. At 75%, 50% and 25% health in that form she tears up the arena, shrinking the battlefield, and her melee speeds up near death.
Strategy
Dodge the telegraphed attacks, such as the grey streaks before a whirlwind strike. Move to the gaps in the ground tears and get behind her for wing combos. Stay mobile in the second form because the shrinking arena makes the blood puddles and bubbles more dangerous, and use Evade to escape the whirlwind pull.
Sources & fact-check
Release facts, mechanics and boss details on this page were checked against these sources on 12 October 2026. Spotted an error? Tell us.