Marvel's Spider-Man (2018): Walkthrough & Boss Guide

This is a short story overview of Marvel's Spider-Man (2018) with notes on its main boss fights. It is not a mission-by-mission walkthrough, and it does not assign events to acts where sources do not. The plot and gameplay follow Wikipedia; boss tips follow SegmentNext's boss guide. There is no wingsuit or dedicated parry in this game (Web Wings and parrying arrived in Spider-Man 2); the closest mechanic is a precise dodge just before impact, which lets Spider-Man retaliate with webbing.

Spider-Man defeats Wilson Fisk, which leaves a criminal power vacuum. The Inner Demons, a masked gang, seize Fisk's illicit assets while searching for Devil's Breath. Spider-Man stops a Demon attack with help from Officer Jefferson Davis. At a re-election event for Mayor Norman Osborn, the Demons attack and kill Davis and others; Peter sees Martin Li leading the assault as Mister Negative but is knocked out. Peter befriends Davis's son, Miles Morales.

Spider-Man learns that Devil's Breath is a lethal bioweapon that Oscorp created by accident while seeking a cure for genetic diseases. Li steals the only sample and demands that Norman surrender. Mary Jane helps Spider-Man defeat Mister Negative, who is sent to the Raft, and the Devil's Breath is recovered.

Otto Octavius, who has a neuromuscular disease, builds four mechanical tentacles controlled by a neural interface. Peter warns that the device could affect his mind, but Otto secretly keeps using it, angry at Norman for cutting their funding. Electro, Vulture, Rhino, Scorpion and Li escape the Raft, capture Spider-Man and take him to Otto, now Doctor Octopus, who releases Devil's Breath in Times Square. An outbreak follows, infecting many people including Aunt May. Norman declares martial law and brands Spider-Man a fugitive.

Spider-Man defeats Electro, Vulture, Rhino and Scorpion. An antidote exists, but Otto takes it after beating Spider-Man. Peter builds an armored suit, defeats Otto atop Oscorp Tower and recovers the antidote. He must choose between saving May and making a vaccine for everyone else, and he saves everyone. May dies, but first says she knows he is Spider-Man and is proud of him.